Green Decoration of Silver Nanoparticles on Hydroxymethylated Lignin-Modified Magnetic Nanoparticles Using Cydonia oblonga Flower Extract: Evaluating of Its Catalytic, Antioxidant and Cytotoxic Effects Against 6 Thyroid Cancer Cell Lines
Abstract
We herein described a biogenic route for the in situ supporting silver nanoparticles on hydroxymethylated lignin (HL) coated Fe3O4 (iron oxide) magnetic nanoparticles using the Cydonia oblonga flower extract (Fe3O4@HL/Ag NPs) and its catalytic activity in the acetylation of alcohols and subsequent its biological activity are investigated. The successful fabrication of Fe3O4@HL/Ag NPs was established by using advanced analytical techniques such as Fourier Transformed Infra-Red spectroscopy, Transmission Electron Microscopy, Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray spectroscopy, elemental mapping and Vibrating Sample Magnetization. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to measure anti-thyroid cancer (on WRO, FTC133, BCPAP, TPC1, K1, and 8505C cells) properties of Fe3O4@HL/Ag NPs nanocomposite. The findings indicate that in 3 days, the cancer cell survival percentage in various dilations reduced as much as the Fe3O4@HL/Ag NPs nanocomposite concentration increased. The best anticancer effect was reported at 1000 μg/ml dilation. MTT findings reveal that IC50 = 146, 181, 250, 141, 170, and 125 µg/ml is a Fe3O4@HL/Ag NPs nanocomposite concentration in which 50% of the WRO, FTC133, BCPAP, TPC1, K1, and 8505C thyroid carcinoma cells. The results indicated that these Fe3O4@HL/Ag NPs nanocomposite could inhibit thyroid cancer cells more strongly than normal cells. Fe3O4@HL/Ag NPs nanocomposite shows high antioxidant effects against DPPH.
- Publication:
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Journal of Polymers and the Environment
- Pub Date:
- August 2024
- DOI:
- 10.1007/s10924-024-03201-z
- Bibcode:
- 2024JPEnv..32.3878M
- Keywords:
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- Thyroid cancer;
- MTT assay;
- Acetylation;
- Silver nanoparticles;
- Cydonia oblonga