On-microparticle construction of endothelialized liver microtissues for drug testing
Abstract
Liver microparticle models crafted with microfluidics and hydrogel techniques. Created portable liver microparticles with consistent endothelium coverage. Enhanced bio-barrier and function in liver constructs. Observed endothelial barrier's effect on prodrug biotransformation.
- Publication:
-
Chemical Engineering Journal
- Pub Date:
- February 2024
- DOI:
- 10.1016/j.cej.2023.148403
- Bibcode:
- 2024ChEnJ.48148403W
- Keywords:
-
- Microfluidics;
- Microparticles;
- Liver;
- Endothelial barrier;
- Drug testing