Fucoidan from Spatoglossum schröederi promotes B16-F10 malignancy features modulation and antimelanoma in vivo activities
Abstract
Although recent advances in targeted and immunotherapy, metastatic melanoma treatment still poses as a challenge, with limited success and a variety of severe adverse effects. Polysaccharides from natural sources have been explored as a new approach to tackle cancer and melanoma treatment limitations, even reaching clinical trials. One prominent group of biological active polysaccharides are fucoidans - sulfated polysaccharides mainly constituted of fucose and obtained from brown seaweed. In the present study, we explored the antimelanoma activities of Fucan A, a highly sulfated fucoidan obtained from Spatoglossum schröederi. Fucan A presented a selective antiproliferative effect against murine melanoma B16-F10 cell line impacting cell cycle progression in concentrations of 100 and 1000 μg⸱mL-1 while also reducing its colony formation and invasive capacity, as well as modulating invasion mechanistically related genes - namely MMP-9, MMP-14, glypican-3 and perlecan. Fucan A also reduced in vivo solid tumor volume in a daily post-cell inoculation treatment regimen with a 100 mg⸱Kg-1 dosage. Additionally, using a 48 h pre-treatment regimen in a reduced dosage (30 mg⸱Kg-1), Fucan A reduced pulmonary metastasis colonization, with limited to non-detectable adverse effects. These results associated with the explorable commercial potential of S. schröederi indicate an interesting compound to be further explored as a possible antimelanoma drug.
- Publication:
-
Algal Research
- Pub Date:
- May 2023
- DOI:
- 10.1016/j.algal.2023.103134
- Bibcode:
- 2023AlgRe..7203134B
- Keywords:
-
- Polysaccharide;
- Fucoidan;
- Cancer;
- Antimelanoma;
- Spatoglossum schröederi