The early detection of diabetes mellitus in younger female obese: A pilot project for GAD65 kit in students community
Abstract
Obesity is a fundamental risk factor with significant correlation to Diabetes Mellitus (DM) development. The incidence of visceral obesity is observed predominantly in females than males. As a consequence, it can be a potential trigger to develop diabetes. Notably, the late diagnostic of diabetes at an individual younger age provides a significant challenge to provide the sensitive and cheaper medical tool for early detection of DM. This pilot study was designed to explore the performance of the GAD65 Rapid Test Kit in early detection of DM, especially in the younger female with obese criteria. Twenty-six individuals were chosen as the sample and had filled the informed consent. The mean of fasting blood glucose was 90 mg/dL, BMI 29.2 kg/m2, and body fat 44.1%. The serum samples were then tested by Reverse-Flow Immunochromatography kit for GAD65 protein. Almost 81% of the samples are positive for GAD65, even with a standard fasting glucose profile. The presence of GAD65 protein in these subjects can predict the autoimmunity probability and beta-cell dysfunction-related diabetes progression. Therefore, the application of this rapid test kit can be proposed as an alternative best way to prevent the significant increase of diabetes, in particular for the younger population.
- Publication:
-
American Institute of Physics Conference Series
- Pub Date:
- January 2023
- DOI:
- 10.1063/5.0129428
- Bibcode:
- 2023AIPC.2634b0018S