ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization
Abstract
Little is known about the molecular determinants of the auditory frequency maps. Our data provide insights into the functional role of the transcription factor ISL1 in the development of auditory neurons and in the formation of the auditory map. In this study, we found that selective genetic deletion of Isl1 by Neurod1Cre resulted in altered molecular and cellular characteristics of auditory neurons, affecting their migration, pathfinding abilities, and formation of peripheral and central processes. This neuronal phenotype was accompanied by hearing impairment, abnormalities in sound processing in the brain, and aberrant auditory behavior. These findings suggest that ISL1 is essential in regulating neuronal differentiation to produce functional auditory neurons.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- September 2022
- DOI:
- 10.1073/pnas.2207433119
- Bibcode:
- 2022PNAS..11907433F