Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory
Abstract
Theta oscillations supported by the medial septum are believed to be a critical mechanism for learning and memory. We report that, in addition to theta oscillations, hippocampal SPW-Rs are important. Enhanced cholinergic activation in the hippocampus during the delay between choices in a spontaneous alternation task abolished SPW-Rs and impaired choice performance in mice. Our findings also demonstrate that the outcome of optogenetic manipulation of a key neurotransmitter, acetylcholine (ACh), depends on the state of the brain at the time of the perturbation.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 2021
- DOI:
- 10.1073/pnas.2016432118
- Bibcode:
- 2021PNAS..11816432Z