Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease
Abstract
Baicalein ameliorated MPP+-induced oxidative stress in SH-SY5Y cells. Baicalein neutralized MPTP-induced motor dysfunction in mice. Baicalein could reverse the oxidative stress features induced by MPTP in mice. Neuroprotective effect of baicalein against MPTP might be mediated by the inhibition of ERK activation.
- Publication:
-
NeuroToxicology
- Pub Date:
- December 2021
- DOI:
- 10.1016/j.neuro.2021.10.003
- Bibcode:
- 2021NeuTx..87..188S
- Keywords:
-
- Baicalein;
- MPTP;
- Neuroprotective;
- Parkinson's disease;
- Oxidative stress