The problem of the position and spin in relativistic quantum mechanics is analyzed in detail. It is definitively shown that the position and spin operators in the Foldy-Wouthuysen representation (but not in the Dirac one) are quantum-mechanical counterparts of the classical position and spin variables. The probabilistic interpretation is valid only for Foldy-Wouthuysen wave functions. The relativistic spin operators are discussed. The spin-orbit interaction does not exist for a free particle if the conventional operators of the orbital angular momentum and the rest-frame spin are used. Alternative definitions of the orbital angular momentum and the spin are based on noncommutative geometry, do not satisfy standard commutation relations, and can allow the spin-orbit interaction.