High-amplitude cofluctuations in cortical activity drive functional connectivity
Abstract
Despite widespread applications, the origins of functional connectivity remain elusive. Here we analyze human functional neuroimaging data. We decompose resting-state functional connectivity across time to assess the contributions of moment-to-moment activity cofluctuations to the overall connectivity pattern. We show that functional connectivity is driven by a small number of high-amplitude frames. We show that these frames are underpinned by a specific mode of brain activity; that the topography of this mode gets modulated during in-scanner tasks; and that high-amplitude frames encode personalized, subject-specific information. In summary, our parameter-free method provides an exact mathematical link between functional connectivity and frame-wise cofluctuations, creating opportunities for studying both static and time-varying functional brain networks.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- November 2020
- DOI:
- 10.1073/pnas.2005531117
- Bibcode:
- 2020PNAS..11728393Z