Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision
Abstract
Spectral sensitivity is determined by the components of the light-sensitive visual pigment: an opsin protein and a covalently bound chromophore. Thyroid hormone signaling has been shown to regulate both the expression of long-wavelength (red) opsin and cyp27c1, an enzyme that converts the vitamin A1-based chromophore to the red-shifted vitamin A2-based form. Here, we show that all three zebrafish thyroid hormone nuclear receptors play a role in mediating induction of cyp27c1 expression in response to thyroid hormone and that mutations in thyroid hormone receptor β result in an absence of red cones and the transfating of red cone precursors into UV cones and horizontal cells in zebrafish. These results demonstrate that thyroid hormone receptors regulate two distinct aspects of long-wavelength vision.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 2020
- DOI:
- 10.1073/pnas.1920086117
- Bibcode:
- 2020PNAS..11715262V