A highly efficient biosensor based on MAPLE deposited hemoglobin on LPGs around phase matching turning point
Abstract
In this paper we report for a highly efficient sensor able to detect low-level glucose in saliva using ultra-sensitive long-period grating (LPG) fibre structure. Hemoglobin was directly immobilized on the structure by matrix-assisted pulsed-laser evaporation (MAPLE) method. Glucose binds to hemoglobin and the result is a glycated hemoglobin, the formation of which we detect. We demonstrate that the implemented technology allows for a clear relationship between glucose concentration and the spectral shift. As a result, a reliable detection of glucose concentration as low as 0.1 mmol/L is demonstrated.
- Publication:
-
Optics Laser Technology
- Pub Date:
- March 2020
- DOI:
- 10.1016/j.optlastec.2019.105907
- Bibcode:
- 2020OptLT.12305907D
- Keywords:
-
- Matrix-assisted pulsed-laser evaporation (MAPLE);
- Long period gratings (LPG);
- Hemoglobin;
- Biosensing;
- Glucose sensor