Development of Feasible and Economic Electrochemical Sensor Based on Manganese Ferrite Nanoparticles (Mn0.2Fe2.8O4) for Determination of a Platelet Aggregation Inhibitor Ticagrelor Drug in Formulations and Human Blood
Abstract
An exquisite and efficient voltammetric sensor was developed for determination of a new antiplatelet agent, Ticagrelor hydrochloride (TIC·HCl). MnxFe3-xO4 nanoparticles (x = 0.0-1.0) were synthesized and investigated using different techniques. X-ray diffraction pattern reveals the phase purity and the formation of crystalline nanoparticles with cubic inverse spinel structures. Mn0.2Fe2.8O4 sample was found to have the smallest particles size (10.72 nm), lattice parameter (0.84 nm), crystal volume (58.70 nm) and highest BET surface area (79.54 m2g-1) compared to the higher Mn2+ content in the other samples. EDX indicated that the composition of Mn0.2Fe2.8O4 was consistent with its estimated molar ratio. Mn0.2Fe2.8O4 nanocomposite was utilized in construction of new electrochemical sensor (Mn0.2Fe2.8O4/CPE). Its effective surface area (0.078 cm2) was higher than that of bare electrode (0.032 cm2) using the slope values of the ipa-v1/2 plots of K4Fe(CN)6. It exhibited a smaller ΔEp (0.14 V) compared to bare CPE (ΔEp = 0.18 V) indicating a fast electron transfer kinetic at the modified electrode surface. Mn0.2Fe2.8O4/CPE offered about one order of magnitude improvement in LOD value (1.39 × 10-9 M) of TIC·HCl compared to the bare CPE (1.53 × 10-8 M). It has a potential sensitivity and selectivity in determination of TIC·HCl in formulations and human plasma.
- Publication:
-
Journal of the Electrochemical Society
- Pub Date:
- January 2020
- DOI:
- 10.1149/1945-7111/ab7e21
- Bibcode:
- 2020JElS..167f7510E