Dorsoventral inversion of the air-filled organ (lungs, gas bladder) in vertebrates: RNAsequencing of laser capture microdissected embryonic tissue
Abstract
How modification of gene expression generates novel traits is key to understanding the evolutionary process. We investigated the genetic basis for the origin of the piscine gas bladder from lungs of ancestral bony vertebrates. Distinguishing these homologous organs is the direction of budding from the foregut during development; lungs bud ventrally and the gas bladder buds dorsally.Highlights The evolution of the piscine gas bladder from ancestral lungs involved a shift in direction of budding from the ventral to dorsal foregut. Tbx5, vital for lung development, shows a concomitant inversion from ventral expression in lung development to dorsal expression in gas bladder development.
- Publication:
-
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (JEZ-B)
- Pub Date:
- September 2020
- DOI:
- 10.1002/jez.b.22998
- Bibcode:
- 2020JEZB..334..325F