Dissolution behavior and thermodynamic properties of apixaban in pure and mixed solvents
Abstract
Research the solubility of apixaban in different solvents. Extended Hildebrand solubility approach (EHSA) was applied to evaluate the co-solvency phenomenon. The experimental data were correlated by some thermodynamic models. The mixing thermodynamic properties of apixaban were evaluated.
- Publication:
-
Journal of Chemical Thermodynamics
- Pub Date:
- May 2020
- DOI:
- 10.1016/j.jct.2019.105949
- Bibcode:
- 2020JChTh.14405949D
- Keywords:
-
- Apixaban;
- Solubility;
- Co-solvency phenomenon;
- Thermodynamic properties