Clustering and dynamics of crowded proteins near membranes and their influence on membrane bending
Abstract
Interactions between crowded cytosols and membrane surfaces are unavoidable inside cells. This all-atom simulation study suggests that nonspecific protein-membrane interactions create a water-rich protein depletion zone between the membrane and the crowded environment, leading to an increased propensity of proteins to aggregate in bulk, but also allow for accelerated diffusion on the surface of the membrane when proteins come closer to the surface occasionally. The simulation results furthermore provide evidence of a nonspecific mechanism for protein-induced membrane curvature formation as a result of crowding near the membrane.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- December 2019
- DOI:
- 10.1073/pnas.1910771116
- Bibcode:
- 2019PNAS..11624562N