CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction
Abstract
Promoting effective CD8+ T cell memory is a primary goal of T cell-based vaccination and immunotherapy strategies. While it is well established that CD4+ T cell help is required for enduring CD8+ T cell memory, how such help contributes to establishing optimal CD8+ T cell memory generation and persistence remains unclear. In this study, we demonstrate that CD4+ help at the time of priming ensures that memory CD8+ T cells are programmed to engage metabolic biological pathways essential for effective recall responses. Such understanding has clear implications for the augmentation of vaccine therapies designed to promote protective T cell immunity.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 2019
- DOI:
- 10.1073/pnas.1808849116
- Bibcode:
- 2019PNAS..116.4481C