Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams
Abstract
Gold nanoparticle (GNP) radio-enhancement is a promising technique to increase the dose deposition in a tumor while sparing neighboring healthy tissue. Previous experimental studies showed effects on cell survival and tumor control for keV x-rays but surprisingly also for MV-photons, proton and carbon-ion beams. In a systematic study, we use the Monte Carlo simulation tool TOPAS-nBio to model the GNP radio-enhancement within a cell as a function of GNP concentration, size and clustering for a wide range of energies for photons, protons and, for the first time, carbon-ions. Moreover, we include water radiolysis, which has been recognized as a major pathway of GNP mediated radio-enhancement.
- Publication:
-
Physics in Medicine and Biology
- Pub Date:
- September 2019
- DOI:
- 10.1088/1361-6560/ab314c
- Bibcode:
- 2019PMB....64q5005R
- Keywords:
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- nanoparticle;
- radioenhancement;
- radiation therapy;
- radiolysis;
- Monte Carlo simulation