Comparative analyzes of 120 Hz Electromagnetic Field, respect the interferon-β and Transfer Factor effect in the recovery of chronic ulcers measuring the frequency of the lymphocytes CD4+ and CD8+ in an animal model
Abstract
We analyze the effects of an Electromagnetic Field of 120 Hz, on the frequency total of T Lymphocytes (CD4+, CD8+) in chronic ulcers, provoked on rats, and judging their effect with respect to the known immunomodulators as Transfer Factor ad Interferon-β. We employed an animal model based on the use of Wistar type rats. The frequency of T lymphocytes (CD4+, CD8+) was measured and the evolution of the ulcers was observed through analyzes of tissue’s biopsies, calculating the ratio (CD4+)/(CD8+) as a monitor variable concerning the immunological impact. Comparing with the negative control, the frequency of T lymphocytes CD4+ presented significant increment (P<0.05) starting from the third day of treatment. Lymphocytes CD8+ diminished significantly (P<0.05). The ulcers from the negative control group in 120 h and with Interferon-β in 96 h, were recovered. Otherwise, with Transfer factor and 120 Hz Electromagnetic field, the ulcer’s time recovery was of 72 h. The results in the latest groups suggest that the total frequency of lymphocytes (CD4+, CD8+) present tendencies toward normal levels. Furthermore, the treatment with 120 Hz Electromagnetic fields show less damage in the ill tissue, analyzing the cellularity with electronic sweep microscopy, implicating less chronic immune activation.
- Publication:
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Journal of Physics Conference Series
- Pub Date:
- June 2019
- DOI:
- 10.1088/1742-6596/1221/1/012056
- Bibcode:
- 2019JPhCS1221a2056G