Benzyl ester dendrimer silicon phthalocyanine based polymeric nanoparticle for in vitro photodynamic therapy of glioma
Abstract
A novel second generation benzyl ester dendrimer silicon phthalocyanine (D-SiPc) was synthesized and encapsulated into amphiphilic block copolymers to form polymeric nanoparticles (D-SiPc@m). The cellular uptake and subcellular localization of D-SiPc@m in U251 glioma cells were studied by confocal laser scanning imaging. The cellular uptake of D-SiPc@m into U251 glioma cells reached the peak after being treatment for 6 h, and D-SiPc@m was localized into both mitochondria and lysosomes. The photodynamic efficacy of D-SiPc@m against U251 glioma cells was evaluated. D-SiPc@m exhibited high photo-cytotoxicity toward U251 glioma cells under laser irradiation. This polymeric nanoparticle could be a promising candidate for therapy of glioma.
- Publication:
-
Journal of Luminescence
- Pub Date:
- March 2019
- DOI:
- 10.1016/j.jlumin.2018.12.012
- Bibcode:
- 2019JLum..207..597M
- Keywords:
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- Silicon phthalocyanine;
- Polymeric nanoparticle;
- Subcellular localization;
- Photodynamic therapy;
- Glioma