Neurotoxicity of ZnO nanoparticles and associated motor function deficits in mice
Abstract
Nano-sized zinc is extensively used by various industries and exposure of humans to these nanoparticles is increasing by the day. Mounting evidence suggests that health hazards are induced by metallic nanoparticles. However, at present, there is insufficient information concerning the impairment of motor functions due to exposure to metallic nanoparticles, particularly zinc oxide (ZnO) nanoparticles. The present study evaluates the toxic effects of ZnO nanoparticles in Swiss albino mice. Motor functions impairments were monitored using beam balance, and pole and footprint tests. Results showed that ZnO nanoparticles cause deficits in normal motor functions. Histopathological investigations revealed significantly (p < 0.01) increased motor cortex nuclear size probably resulting from neuroinflammation/neuronal damage. Overall, it is concluded that ZnO nanoparticles induce neurotoxicity resulting in motor function impairments.
- Publication:
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Applied Nanoscience
- Pub Date:
- June 2019
- DOI:
- Bibcode:
- 2019ApNan..10..177Y
- Keywords:
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- Metallic nanoparticles;
- ZnO nanoparticles;
- Motor function impairment;
- Histopathology;
- Neurotoxicity