New probiotics for enhancement of human colonial resistance in artificial environment: achievements and prospective
Abstract
Planned interplanetary missions require elaboration of sufficient means to enhance colonial resistance of space crew members. Previous studies reveal decrease of protection activity of indigenous microflora of cosmonauts, thus exogenous contamination could be dramatically easified.Today there are at least four main microbial risk factors1. Risk of auto- and cross infections2. Risk of sapronose-like infection from alternative sources in confined habitat (e.g. contaminated surfaces and LSS elements)3. Risk of microbial contamination from outer space during EVA4. Risk of contamination by microbial community, formed on visiting planet. To avoid microbial risks reliable and fit prophylactic means should be elaborated. Among broad range of ecologically compatible means aimed to improve colonial resistance, autoprobiotics seem to be one of the most perspective groups. We have successfully tested several kinds of probiotics, based on autochthonous bifidobacteria, lactobacilli and enterococci strains in different experiments in long-term isolation, including "Mars-500". The tremendous advantage of autoprobiotics is that there is no problem for adhesion in the biotope, and that it has no allergic impact on human organism. The form of consumption is different: tablets, collagen stripes, ampoules, sour milk products, sprays. Other perspective group of probiotics are based on collection strains, which are well known as protective strains, but still never used as probiotic medicines. For example Corynebacterium pseudodyphteriticum for treatment of high respiratory tract, was tested in different dry immersion studies to decrease or to eradicate Staphtlococcus aureus, Veillonella parvula is a good antagonist versus periodontial pathogens.The third group of prospective means form combined preparates containing probiotics together with other substances. For example, simulator of nasal secretion, containing bacterial substance together with hyaluronic acid and lysozyme was successfully tested in dry immersion studies. The list of the these latter means will be expanded in our future studies.
- Publication:
-
42nd COSPAR Scientific Assembly
- Pub Date:
- July 2018
- Bibcode:
- 2018cosp...42E1540I