Superfast DNA replication causes damage in cancer cells
Abstract
Inhibitors of PARP proteins are used in cancer treatment. It emerges that PARP inhibitors exert their effect by accelerating DNA replication to a speed at which DNA damage occurs.
- Publication:
-
Nature
- Pub Date:
- June 2018
- DOI:
- 10.1038/d41586-018-05501-6
- Bibcode:
- 2018Natur.559..186Q