GABA A receptor modulation by the Antisecretory Factor on cerebellar granule cells
Abstract
The Antisecretory Factor (AF, Mw 41kD) is an endogenous protein, found in all mammalian tissues. AF acts in vivo by counteracting intestinal hypersecretion and various forms of inflammations. The detailed in vitro AF action on the cellular level is unknown. Using an in vitro neuronal model (granular cells from rat small brain) we studied AF action on ionotropic GABA A receptors. A facilitatory activity, due to increased GABA A receptors expression, was demonstrated on the neuronal plasma membrane in response to AF influence. This effect may result in inhibition of intestinal secretomotor cells.
- Publication:
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Nuovo Cimento C Geophysics Space Physics C
- Pub Date:
- May 2018
- DOI:
- 10.1393/ncc/i2018-18115-7
- Bibcode:
- 2018NCimC..41..115G