The Efficacy of Noni Fruit Methanol Extract (Morinda citrofolia) to Brain Derived Neurotrophic Factor (BDNF) on Male Swiss Webster Mice Induced By Immobilization Stress

Aging process is associated with declines in certain cognitive abilities such as learning and memory ability and impact on high risk of dementia, physical disability and death. Oxidative stress is believed as basic mechanism of aging process. Morinda citrofolia (Noni fruit) has long been used as a traditional plant in worldwide and was proven empirically in traditional medicine as antioxidant. This study was to determine the effect of noni fruit methanol extract on BDNF levels in white mice of Swiss Webster strain induced by immobilization stress. This research is experimental study with post test only control group design. Male Swiss Webster Mice were induced by immobilization stress and randomized into seven groups (5 mice/groups). The first group was negative control group; Group 2,3,4,5 and 6 was given treatment with varied concentrations of Morinda citrofolia (50, 100, 200, 400 and 800 mg/kgBW). Vitamin E (70 mg/kgBW), standart antioxidant was used as positive control (Group 7). Brain BDNF level of the white mice were measured by using ELISA method. Experiment result showed that treatment with Morinda citrofolia extract (50, 100, 200,400 mg/kgBW) and Vitamin E 70 mg/kg BW showed a sigificant differences in BDNF level compare with the negative control rats. There is no significant differences between 200 mg/kgBW Metanol Extract of Morinda citrofolia group and vitamin E (p = 0,301; p > 0,05). Metanol Extract of Morinda citrofolia could prevent the decrement of BDNF level due to stress.