Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study
Abstract
Concentrations of non-dioxin-like PCBs in maternal blood during pregnancy were measured. DNA methylation of H19 and LINE-1 in cord blood was examined. Prenatal PCB-exposures were associated with increased H19 and LINE-1 methylation levels. The association was gender-specific (observed in female infants only). The association was parity-specific (observed in primiparous mothers only).
- Publication:
-
Toxicology
- Pub Date:
- September 2017
- DOI:
- 10.1016/j.tox.2017.08.010
- Bibcode:
- 2017Toxgy.390..135K
- Keywords:
-
- AHR;
- aromatic hydrocarbon receptor;
- CI;
- confidence interval;
- DecaCB;
- decachlorinated biphenyl;
- DMR;
- differentially methylated region;
- DL-PCB;
- dioxin-like polychlorinated biphenyl;
- HeptaCB;
- heptachlorinated biphenyl;
- HexaCB;
- hexachlorinated biphenyl;
- IGF-2;
- insulin-like growth factor-2;
- LINE-1;
- long interspersed nuclear element-1;
- NonaCB;
- nonachlorinated biphenyl;
- NDL-PCB;
- non-dioxin-like polychlorinated biphenyl;
- OctaCB;
- octachlorinated biphenyl;
- PentaCB;
- pentachlorinated biphenyl;
- PCB;
- polychlorinated biphenyl;
- TetraCB;
- tetrachlorinated biphenyl;
- TriCB;
- trichlorinated biphenyl;
- Polychlorinated biphenyl;
- Prenatal exposure;
- H19;
- Long interspersed nuclear element-1;
- DNA methylation;
- Gender difference