Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Abstract
Alternative RNA splicing and the spliceosome machinery have been implicated in cancer progression. A genome-wide CRISPR screen identified the RNA processing factor heterogeneous nuclear ribonucleoprotein L (HNRNPL) as required for prostate cancer growth by regulating alternative RNA splicing and circular RNA formation. HNRNPL and its RNA clients are overexpressed during prostate cancer progression, supporting their potential role as therapeutic targets.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 2017
- DOI:
- 10.1073/pnas.1617467114
- Bibcode:
- 2017PNAS..114E5207F