Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice
Abstract
Neocortical beta is one of the most prominent signatures of neural activity measured noninvasively in humans. Beta expression is a strong predictor of healthy and pathological perceptual and motor performance. However, there is considerable debate as to whether beta itself is causally important in information and disease processes. Key to resolving this debate is understanding the neural mechanisms inducing beta. Here, building on prior work, we combined human magnetoencephalography, computational modeling, and laminar recordings in mice and monkeys to establish and test a new theory explaining the emergence of spontaneous transient neocortical beta events in somatosensory and frontal cortex. Our results enable a principled understanding of neocortical beta and can help guide studies seeking to understand its relation to function.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- August 2016
- DOI:
- 10.1073/pnas.1604135113
- Bibcode:
- 2016PNAS..113E4885S