Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis
Abstract
Claudin-1 (CLDN1), which is thought to be a key gene for human skin disease, especially atopic dermatitis (AD), encodes the dominant claudin responsible for the paracellular barrier at tight junctions in the epidermis. Although decreased CLDN1 expression levels are reported in AD patients, it has been difficult to study how CLDN1 contributes to AD development, mainly because Cldn1 knock-out mice die within 1 d after birth from dehydration. In this report, we reproduced features of human AD in mice, by systematically regulating the Cldn1 expression level. Our experimental approach contributes to the understanding of AD's etiology and suggests a therapeutic target for this disorder.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- July 2016
- DOI:
- 10.1073/pnas.1525474113
- Bibcode:
- 2016PNAS..113E4061T