An application of optical coherence tomography and a smart polymer gel to construct an enzyme-free sugar sensor
Abstract
This work reports a novel enzyme-free sugar sensor development based on optical coherence tomography (OCT) and a 3-acrylamidophenylboronic acid-acrylamide copolymer gel that swells when it binds sugar molecules. Utilizing OCT to measure the gel swelling in the presence of glucose and fructose, selected as model targets, the sensor provided a linear range of 2.5-20.0 mM for glucose and 0.01-0.20 mM for fructose detections with a good sensitivity for both sugars under optimal conditions. With some further improvements, the sensor could be used in harsh conditions that are not suitable for enzyme-based sugar sensors and for highly visible light-absorbing solutions.
- Publication:
-
Applied Physics B: Lasers and Optics
- Pub Date:
- June 2016
- DOI:
- 10.1007/s00340-016-6445-5
- Bibcode:
- 2016ApPhB.122..166O