TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling
Abstract
Close appositions between the endoplasmic reticulum (ER) and the plasma membrane in mammalian cells have essential roles in cellular lipid metabolism and in cytoplasmic calcium signaling. Although recent investigations have yielded considerable insight into the structural basis for lipid transfer at ER-plasma membrane junctions, little is known about the proteins that organize junctions for calcium signaling. Our data show that the ER membrane protein transmembrane protein 110 (TMEM110) supports the maintenance of ER-plasma membrane junctions competent for calcium signaling and acts in concert with other proteins in the dynamic remodeling of the junctions during signaling.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- December 2015
- DOI:
- 10.1073/pnas.1521924112
- Bibcode:
- 2015PNAS..112E7083Q