In utero exposure of mice to diesel exhaust particles affects spatial learning and memory with reduced N-methyl-d-aspartate receptor expression in the hippocampus of male offspring
Abstract
We characterized the components of diesel exhaust particles (DEPs). Effects of prenatal exposure to DEPs were examined in mice. Maternal prenatal exposure affected spatial learning and memory in male offspring. DEP exposure reduced hippocampal N-methyl-d-aspartate receptor expression.
- Publication:
-
NeuroToxicology
- Pub Date:
- September 2015
- DOI:
- 10.1016/j.neuro.2015.08.009
- Bibcode:
- 2015NeuTx..50..108Y
- Keywords:
-
- Diesel exhaust particles;
- Maternal exposure;
- Learning;
- Memory;
- N-methyl-d-aspartate receptor;
- Hippocampus