DNA damage in neurodegenerative diseases
Abstract
Oxidative DNA damage is one of the earliest detectable events in the neurodegenerative process. The mitochondrial DNA is more vulnerable to oxidative attack than the nuclear DNA. Cytogenetic damage has been largely documented in Alzheimer's disease patients. The question of whether DNA damage is cause or consequence of neurodegeneration is still open. Increasing evidence links DNA damage and repair with epigenetic phenomena.
- Publication:
-
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Pub Date:
- June 2015
- DOI:
- 10.1016/j.mrfmmm.2014.11.010
- Bibcode:
- 2015MRFMM.776...84C
- Keywords:
-
- Alzheimer's disease;
- Parkinson's disease;
- Amyotrophic Lateral Sclerosis;
- DNA damage;
- Chromosome damage;
- Epigenetics