Diazonium salt-mediated synthesis of new amino, hydroxy, propargyl, and maleinimido-containing superparamagnetic Fe@C nanoparticles as platforms for linking bio-entities or organocatalytic moieties
Abstract
New magnetic Fe@C nanoparticles in the size range of about 20-50 nm functionalized with amino, hydroxy, propargyl, or maleinimido groups were synthesized by reaction with aryl diazonium salts. Aryl diazonium salts wherein the functional groups are linked via a sulfonamide moiety turned out to be advantageous over those with direct linkage. The obtained Fe@C nanoparticles represent magnetic nanoplatforms for linking bio-entities and organocatalysts using amide formation, CuAAC, or thiol-ene click chemistry as exemplified by selected examples. The Fe@C nanoparticles obtained exhibit supramolecular behavior with high value of saturation magnetization rendering them attractive for practical applications in biomedicine and organocatalysis.
- Publication:
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Journal of Nanoparticle Research
- Pub Date:
- September 2015
- DOI:
- 10.1007/s11051-015-3167-2
- Bibcode:
- 2015JNR....17..379B
- Keywords:
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- Magnetic nanoparticles;
- Click chemistry;
- Diazonium salts;
- Biotin;
- Sulfonamides;
- Carbon shell