Resection is a major repair pathway of heavy ion-induced DNA lesions
Abstract
Space radiation include densely ionizing heavy ions, which can produce clustered DNA damage with high frequency in human cells. Repair of these complex lesions is generally assumed to be more difficult than for simple double-strand breaks. We show here that human cells use break resection with increasing frequency after exposure to heavy ions. Resection can lead to misrepair of the DNA lesion, via microhomology mediated end-joining. Resection can therefore be responsible for the increased effectiveness of heavy ions in the induction of mutations and genetic late effects.
- Publication:
-
40th COSPAR Scientific Assembly
- Pub Date:
- 2014
- Bibcode:
- 2014cosp...40E.763D