Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics
Abstract
We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ). FISSEQ-BOINC exhibits different properties from BOINC, which relies on bulk nucleic acid sequencing. FISSEQ-BOINC could become a scalable approach for mapping whole-mammalian-brain connectomes with rich molecular annotations.
- Publication:
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arXiv e-prints
- Pub Date:
- April 2014
- DOI:
- 10.48550/arXiv.1404.5103
- arXiv:
- arXiv:1404.5103
- Bibcode:
- 2014arXiv1404.5103M
- Keywords:
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- Quantitative Biology - Neurons and Cognition