ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells
Abstract
Human cytomegalovirus (HCMV)-infected cells and tumor cells produce similar alterations in glucose metabolism, including increasing glucose uptake and glycolysis and redirecting glucose carbon to support synthesis of biomolecules. We show that HCMV infection induces the glucose-responsive transcriptional factor carbohydrate-response element binding protein to reprogram glucose metabolism to support lipid and nucleotide synthesis. This study provides insight into viral mechanisms of pathogenesis.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 2014
- DOI:
- 10.1073/pnas.1310779111
- Bibcode:
- 2014PNAS..111.1951Y