Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe
Abstract
This paper describes the use of natural variation to investigate a cell-autonomous function in the experimentally well-studied model Schizosaccharomyces pombe. We determined the genome structure of a natural isolate with four chromosomes, rather than the three present in the laboratory strain and in all other natural isolates studied to date. Two of the centromeres in this variant lack adjacent heterochromatin but assemble their kinetochores normally, demonstrating that kinetochore and heterochromatin assembly are autonomous in this organism.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 2014
- DOI:
- 10.1073/pnas.1216934111
- Bibcode:
- 2014PNAS..111.1903B