Electrophoresis of a DNA coil near a nanopore
Abstract
Motivated by DNA electrophoresis near a nanopore, we consider the flow field around an “elongated jet,” a long thin source which injects momentum into a liquid. This solution qualitatively describes the electro-osmotic flow around a long rigid polymer, where due to electrohydrodynamic coupling, the solvent receives momentum from the electric field. Based on the qualitative behavior of the elongated jet solution, we develop a coarse-grained scheme which reproduces the known theoretical results regarding the electrophoretic behavior of a long rigid polymer and a polymer coil in a uniform field, which we then exploit to analyze the electrophoresis of a polymer coil in the nonuniform field near a nanopore.
- Publication:
-
Physical Review E
- Pub Date:
- April 2013
- DOI:
- 10.1103/PhysRevE.87.042723
- arXiv:
- arXiv:1306.4602
- Bibcode:
- 2013PhRvE..87d2723R
- Keywords:
-
- 87.15.Tt;
- 87.14.gk;
- Electrophoresis;
- DNA;
- Physics - Biological Physics;
- Condensed Matter - Soft Condensed Matter;
- Quantitative Biology - Biomolecules
- E-Print:
- 10 pages, 4 figures