Development of a histone deacetylase 6 inhibitor and its biological effects
Abstract
We discovered a hydroxamic acid-based small-molecule N-hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide selectively inhibits histone deacetylase 6 catalytic activity in vivo and in vitro.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- September 2013
- DOI:
- Bibcode:
- 2013PNAS..11015704L