Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis
Abstract
A novel, compact-sized (19 cm × 16 cm) and portable (500 g) magnetic resonance relaxometry system is designed and developed. We overcame several key engineering barriers so that magnetic resonance technology can be potentially used for disease diagnosis-monitoring in point-of-care settings, directly on biological cells and tissues. The whole system consists of a coin-sized permanent magnet (0.76 T), miniaturized radio-frequency microcoil probe, compact lumped-circuit duplexer, and single board 1-W power amplifier, in which a field programmable gate array -based spectrometer is used for pulse excitation, signal acquisition, and data processing. We show that by measuring the proton transverse relaxation rates from a large pool of natural abundance proton-nuclei presence in less than 1 μL of red blood cells, one can indirectly deduce the relative magnetic susceptibility of the bulk cells within a few minutes of signal acquisition time. Such rapid and sensitive blood screening system can be used to monitor the fluctuation of the bulk magnetic susceptibility of the biological cells (e.g., human blood cells), where unusual state of the bulk magnetic susceptibility is related to a number of diseases.
- Publication:
-
Review of Scientific Instruments
- Pub Date:
- September 2012
- DOI:
- 10.1063/1.4754296
- Bibcode:
- 2012RScI...83i5115P
- Keywords:
-
- biological tissues;
- biomedical equipment;
- biomedical MRI;
- blood;
- cellular biophysics;
- diseases;
- magnetic susceptibility;
- medical image processing;
- patient monitoring;
- permanent magnets;
- portable instruments;
- 87.61.Tg;
- 87.85.Ox;
- 87.61.Ff;
- 87.19.X-;
- Clinical applications;
- Biomedical instrumentation and transducers including micro-electro-mechanical systems;
- Instrumentation;
- Diseases