Photodynamic therapy influence on anti-cancer immunity
Abstract
The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of IL-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce the tumor. These findings indicate the important role of anti-cancer immune response in the long-term tumor control after PDT.
- Publication:
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Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series
- Pub Date:
- February 2010
- DOI:
- 10.1117/12.853588
- arXiv:
- arXiv:0911.4074
- Bibcode:
- 2010SPIE.7547E..04I
- Keywords:
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- Quantitative Biology - Cell Behavior;
- Quantitative Biology - Populations and Evolution
- E-Print:
- 9 pages, 5 figures