Influence of a Small Fraction of Individuals with Enhanced Mutations on a Population Genetic Pool
Abstract
It has been observed that a higher mutation load could be introduced into the genomes of children conceived by assisted reproduction technology (fertilization in-vitro). This generates two effects — slightly higher mutational pressure on the whole genetic pool of population and inhomogeneity of mutation distributions in the genetic pool. Computer simulations of the Penna ageing model suggest that already a small fraction of births with enhanced number of new mutations can negatively influence the whole population.
- Publication:
-
International Journal of Modern Physics C
- Pub Date:
- 2009
- DOI:
- 10.1142/S0129183109014333
- arXiv:
- arXiv:0903.3017
- Bibcode:
- 2009IJMPC..20.1271C
- Keywords:
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- Population genetics;
- ageing;
- Penna model;
- in-vitro fertilization;
- Quantitative Biology - Populations and Evolution
- E-Print:
- 10 pages including 6 figures