Chemical Synthesis of Glycosylphosphatidylinositol (GPI) Anchors and GPI-Linked Structures
Abstract
Glycosylphosphatidylinositols (GPIs) are a class of natural glycolipids that are ubiquitously expressed by eukaryotic cells. One of the fundamental functions of GPIs is to anchor proteins, glycoproteins, and other molecules onto cell surfaces. The structures of GPIs are diverse and heterogeneous. To obtain homogeneous and well-defined GPIs for various studies, the chemical synthesis of GPIs has become a hot topic. This chapter summarizes the recent progress in the chemical synthesis of GPIs as well as related structures, such as the GPI-linked peptides and glycopeptides.
- Publication:
-
Glycoscience
- Pub Date:
- 2008
- DOI:
- 10.1007/978-3-540-30429-6_42
- Bibcode:
- 2008glyc.book.1697G