Chance and necessity in chromosomal gene distributions
Abstract
By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We have used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in S. cerevisiae and bi-directional terminators in E. coli.
- Publication:
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arXiv e-prints
- Pub Date:
- March 2008
- DOI:
- 10.48550/arXiv.0803.1261
- arXiv:
- arXiv:0803.1261
- Bibcode:
- 2008arXiv0803.1261H
- Keywords:
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- Quantitative Biology - Genomics
- E-Print:
- Main text plus supplementary text