Modeling Interactome: Scale-Free or Geometric?
Abstract
Networks have been used to model many real-world phenomena to better understand the phenomena and to guide experiments in order to predict their behavior. Since incorrect models lead to incorrect predictions, it is vital to have a correct model. As a result, new techniques and models for analyzing and modeling real-world networks have recently been introduced. One example of large and complex networks involves protein-protein interaction (PPI) networks. We demonstrate that the currently popular scale-free model of PPI networks fails to fit the data in several respects. We show that a random geometric model provides a much more accurate model of the PPI data.
- Publication:
-
arXiv e-prints
- Pub Date:
- April 2004
- DOI:
- 10.48550/arXiv.q-bio/0404017
- arXiv:
- arXiv:q-bio/0404017
- Bibcode:
- 2004q.bio.....4017P
- Keywords:
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- Molecular Networks
- E-Print:
- 53 pages, 18 figures, 5 tables