Antigen Bias in T Cell Cross-Priming
Abstract
Activated CD8+ T cells detect virally infected cells and tumor cells by recognition of major histocompatibility complex class I-bound peptides derived from degraded, endogenously produced proteins. In contrast, CD8+ T cell activation often occurs through interaction with specialized antigen-presenting cells displaying peptides acquired from an exogenous cellular source, a process termed cross-priming. Here, we observed a marked inefficiency in exogenous presentation of epitopes derived from signal sequences in mouse models. These data indicate that certain virus- and tumor-associated antigens may not be detected by CD8+ T cells because of impaired cross-priming. Such differences in the ability to cross-present antigens should form important considerations in vaccine design.
- Publication:
-
Science
- Pub Date:
- May 2004
- DOI:
- 10.1126/science.1096268
- Bibcode:
- 2004Sci...304.1314W
- Keywords:
-
- IMMUNOLOGY