Supramolecular Assembly of Biomolecules
Abstract
At present there is a surge in interest in biophysical research in elucidating collective interactions between cellular proteins and associated biomolecules leading to supramolecular structures, with the ultimate goal of relating structure to function. The nerve cell cytoskeleton, provides a rich example of a network of interacting neurofilaments, microtubules, both single and bundles, and filamentous actin, where the structure and structure-function correlations remain poorly understood. We present synchrotron x-ray diffraction, electron microscopy, and optical imaging data, in reconstituted systems of microtubules and neurofilaments from bovine brain and spinal cord, which reveal supramolecular assemblies of bundles, networks, and kinetically driven structural transitions from bundles to raft-like assemblies of tubulin rings.
- Publication:
-
APS March Meeting Abstracts
- Pub Date:
- March 2004
- Bibcode:
- 2004APS..MAR.B4005S