Bone metabolism and formation generation bred mice in a 2G environment
Abstract
We examined the influence of G-force on bone formation (Exp.1) and bone metabolism (Exp.2) on generation bred mice in a 2G environment. [Materials and Method] We made the centrifugation G load breeding machine that we can breed mouse in G load environment. Exp.1: We measured the body length, length of thighbone and pelvis, width of thighbone, pelvis and fourth cervical vertebra in mature mice from the photograph of mice by X-ray. Exp.2: Calcium, phosphorus, magnesium and strontium were analyzed on thighbone, cervical vertebrae and lumbar vertebrae respectively. [Results] Exp.1: The result showed that the average of body length of control mice was 107.9+/-1.5 mm, a decrease approximately 7.9mm in body length in the G-forced mice. Length and width of thighbone and pelvis were miniaturized (length: 1.6%, width: 7.7% respectively) in the G-forced mice. However, width of cervical vertebrae in the Gforced mice was not different in control mice. Exp.2: The concentration of calcium and phosphorus of the thighbone in the G-forced mice was less than the control mice. However, that of the cervical vertebrae in G-forced mice was not different from the control mice. [Conclusion] Bone of mice adapted in a 2G environment. The results showed that the body length, thighbone and pelvis were miniaturized in the G-force mice. However, there were not any differences in the size of cervical vertebra. And cervical vertebra was promoted mineralization.
- Publication:
-
34th COSPAR Scientific Assembly
- Pub Date:
- 2002
- Bibcode:
- 2002cosp...34E..21K