Lipid raft aggregation during the formation of the immunological synapse: quantitative mapping and simulations
Abstract
Lipid raft aggregation during formation of the immunological synapse in T-cells was explored using both experimental results from immunofluorescence imaging and computer simulations. Profiles of lipid raft distributions in the capping region relative to other protein species are presented, and compared for various experimental approaches. We also discuss a model for the dynamical formation of the synapse which incorporates different methods of transport for the lipid rafts themselves as well as other important species, including T-cell receptors and the major histocompatibility complex (MHC)/peptide complex, and we relate these to experimental findings.
- Publication:
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APS March Meeting Abstracts
- Pub Date:
- March 2002
- Bibcode:
- 2002APS..MARW29010A