Statistical mechanics of warm and cold unfolding in proteins
Abstract
We present a statistical mechanics treatment of the stability of globular proteins which takes explicitly into account the coupling between the protein and water degrees of freedom. This allows us to describe both the cold and the warm unfolding, thus qualitatively reproducing the known thermodynamics of proteins.
- Publication:
-
European Physical Journal B
- Pub Date:
- November 1998
- DOI:
- arXiv:
- arXiv:cond-mat/9711291
- Bibcode:
- 1998EPJB....6..157H
- Keywords:
-
- PACS. 87.10.+e General;
- theoretical;
- and mathematical biophysics (including logic of biosystems;
- quantum biology;
- and relevant aspects of thermodynamics;
- information theory;
- cybernetics;
- and bionics) - 05.70.Jk Critical point phenomena - 82.20.Db Statistical theories (including transition state);
- 87.10.+e;
- 05.70.Jk;
- 82.20.Db;
- General theory and mathematical aspects;
- Critical point phenomena;
- Transition state theory and statistical theories of rate constants;
- Condensed Matter;
- Nonlinear Sciences - Chaotic Dynamics;
- Quantitative Biology
- E-Print:
- 5 pages, REVTex, 4 Postscript figures